Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200851 | 0.88 | BRD4 (0.45) | GAA | |
| SCHEMBL5421629 | 0.84 | LMNA (0.41) | ALDH1A1LMNAMCOLN3TSHRKDM4E | |
| SCHEMBL5421626 | 0.84 | LMNA (0.41) | ALDH1A1LMNAMCOLN3TSHRKDM4E | |
| SCHEMBL4574792 | 0.83 | MCOLN3 (0.39) | POLBALDH1A1KMT2ALMNAMCOLN3 | |
| SCHEMBL14013930 | 0.81 | ALDH1A1 (0.54) | POLBALDH1A1KMT2ALMNAL3MBTL1 | |
| SCHEMBL9686466 | 0.80 | CYP2D6 (0.47) | POLBALDH1A1KMT2ALMNAMCOLN3 | |
| SCHEMBL4595283 | 0.80 | CYP2D6 (0.47) | POLBALDH1A1KMT2ALMNAMCOLN3 | |
| SCHEMBL12429274 | 0.80 | PPM1D (0.30) | — | |
| SCHEMBL2197409 | 0.79 | HSD11B1 (0.43) | ALDH1A1GAA | |
| SCHEMBL8474798 | 0.76 | POLB (0.50) | POLBALDH1A1KMT2ALMNAMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |