SCHEMBL4574564

SCHEMBL4574564

NCCCCOCc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.56
MAOA P21397 1/20 0.54
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
SSTR1 P30872 1/20 0.47
SSTR2 P30874 1/20 0.47
SSTR4 P31391 1/20 0.47
SSTR3 P32745 1/20 0.47
SSTR5 P35346 1/20 0.47
IDO1 P14902 1/20 0.46
HRH4 Q9H3N8 1/20 0.46
HRH3 Q9Y5N1 1/20 0.46
AGXT P21549 1/20 0.45
NAAA Q02083 1/20 0.43
CYP2A6 P11509 1/20 0.43
HTR2A P28223 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TAAR1 Q96RJ0 1/20 0.43
LOXL2 Q9Y4K0 1/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4230078 0.98 L3MBTL1 (0.54) TSHRMAOATDP1L3MBTL1SSTR1
SCHEMBL15923248 0.98 L3MBTL1 (0.54) TSHRMAOATDP1L3MBTL1SSTR1
SCHEMBL8893085 0.98 L3MBTL1 (0.54) TSHRMAOATDP1L3MBTL1SSTR1
SCHEMBL6268086 0.98 L3MBTL1 (0.54) TSHRMAOATDP1L3MBTL1SSTR1
Hydrochloric Acid SCHEMBL9781752 0.96 L3MBTL1 (0.53) TSHRMAOATDP1L3MBTL1SSTR1
Hydrochloric Acid SCHEMBL20492261 0.96 L3MBTL1 (0.53) TSHRMAOATDP1L3MBTL1SSTR1
SCHEMBL26813047 0.94 TSHR (0.54) TSHRMAOATDP1L3MBTL1SSTR1
SCHEMBL2782 0.94 TSHR (0.58) TSHRMAOATDP1L3MBTL1IDO1
SCHEMBL1568954 0.90 TSHR (0.50) TSHRMAOATDP1L3MBTL1SSTR1
SCHEMBL27375031 0.90 TSHR (0.54) TSHRMAOATDP1L3MBTL1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4608810-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF USE TO TREAT HYPOPARATHYROIDISM AND OSTEOPOROSIS Septerna, Inc. (US) 2025-09-03 EP disclosed
CN-119325378-A Cannabinoid receptor 1 antagonists/inverse agonists and uses thereof 柯巴斯医药有限公司 2025-01-17 CN disclosed
WO-2024091498-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF USE TO TREAT HYPOPARATHYROIDISM AND OSTEOPOROSIS SEPTERNA, INC. (US) 2024-05-02 WO disclosed
US-20230121302-A1 METHODS OF IRON CATALYZED C-H BOND AMINATION VERSITECH LIMITED (CN) 2023-04-20 US disclosed
CN-111410663-B Preparation of double-target point synergistic compound and application of compound in field of diseases related to multiple myeloma 北京桦冠医药科技有限公司 2022-11-08 CN disclosed
EP-3052134-B1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME (US) 2021-05-05 EP disclosed
CN-111410663-A Preparation of double-target point synergistic compound and application of compound in field of diseases related to multiple myeloma 北京桦冠医药科技有限公司 2020-07-14 CN disclosed
CN-105792852-B Glucose-responsive insulin conjugates 默沙东公司 2019-12-10 CN disclosed
US-20180110863-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES MERCK SHARP & DOHME CORP. (US) 2018-04-26 US disclosed
EP-3280450-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES Merck Sharp & Dohme Corp. (US) 2018-02-14 EP disclosed
WO-2008065500-A2 HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS PFIZER PRODUCTS INC. (US) 2008-06-05 WO disclosed
US-6344473-B1 NITRIC OXIDE SYNTHASE INHIBITOR G.D. SEARLE & CO. 2002-02-05 US disclosed
US-6136829-A NITRIC OXIDE SYNTHETASE INHIBITORS G.D. SEARLE & CO. (US) 2000-10-24 US disclosed
EP-1000041-A1 1,3-DIAZA- HETEROCYCLES AND THEIR USE AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 2000-05-17 EP disclosed
US-5981556-A USEFUL IN TREATMENT OF INFLAMMATORY CONDITIONS AFFECTING THE JOINTS, FOR EXAMPLE ARTHRITIS, AND ALSO INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, MIGRAINE G.D. SEARLE & CO. (US) 1999-11-09 US disclosed
US-5958958-A ANTIINFLAMMATORY AGENT; HYPOTENSIVE AGENT G.D. SEARLE & CO. (US) 1999-09-28 US disclosed
WO-1999005131-A1 1,3-DIAZA- HETEROCYCLES AND THEIR USE AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 1999-02-04 WO disclosed
US-5583259-A FOR RESOLVING RACEMIC MIXTURES LES LABORATOIRES BEECHAM S.A. (FR) 1996-12-10 US disclosed
EP-0570443-B1 AMINOALCOHOLS USEFUL AS OPTICAL RESOLVING AGENTS SMITHKLINE BEECHAM LAB (FR) 1995-11-29 EP disclosed
US-4592973-A Hydrophobic microporous membrane CASTLE TECHNOLOGY CORP. (US) 1986-06-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180110863-A1 GLUCOSE-RESPONSIVE INSULIN CONJUGATES GPR119, INSR, IRS1 TSHR 281/4885MAOA 3545/4885TDP1 4593/4885
US-20230121302-A1 METHODS OF IRON CATALYZED C-H BOND AMINATION FTH1, FECH, HCCS TSHR 1353/4885MAOA 45/4885TDP1 4855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.