Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 7/20 | 0.52 |
| ▸ | CA2 | P00918 | 7/20 | 0.52 |
| ▸ | CA9 | Q16790 | 5/20 | 0.52 |
| ▸ | CA5A | P35218 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026994 | 0.89 | HSPB1 (0.75) | HSPB1POLBCA1CA2CA9 | |
| SCHEMBL536 | 0.89 | HSPB1 (0.75) | HSPB1POLBCA1CA2CA9 | |
| Fluoride SCHEMBL4551986 | 0.86 | HSPB1 (0.72) | HSPB1POLBGAAKCNJ1KCNH2 | |
| Water SCHEMBL28147677 | 0.86 | HSPB1 (0.72) | HSPB1POLBGAAKCNJ1KCNH2 | |
| Fluoride SCHEMBL4551988 | 0.86 | HSPB1 (0.72) | HSPB1POLBGAAKCNJ1KCNH2 | |
| SCHEMBL28001935 | 0.86 | HSPB1 (0.72) | HSPB1POLBGAAKCNJ1KCNH2 | |
| SCHEMBL6038264 | 0.85 | HSPB1 (0.60) | HSPB1POLBCA1CA2CA9 | |
| Formaldehyde SCHEMBL28237406 | 0.84 | HSPB1 (0.69) | HSPB1POLBGAAKCNJ1KCNH2 | |
| Ethylene SCHEMBL27864908 | 0.84 | HSPB1 (0.69) | HSPB1POLBGAAKCNJ1KCNH2 | |
| Ethane SCHEMBL28251595 | 0.84 | HSPB1 (0.69) | HSPB1POLBGAAKCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137703-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECH LIMITED (GB) | 2026-05-21 | — | — | US | disclosed |
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |
| CN-109153642-A | Indoles and azaindole halogenated allylamine derivatives inhibitors of lysyloxidase and application thereof | 法玛西斯有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-109071533-A | Halogenated allylamine indoles and 7-azaindole derivatives inhibitor of lysyloxidase and application thereof | 法玛西斯有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108698982-A | FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF | 日产化学工业株式会社 | 2018-10-23 | — | — | CN | disclosed |
| CN-107257788-A | Benzenesulfonamide derivatives as inverse agonists of the retinoid-related orphan receptor gamma (ROR gamma (t)) | 盖尔德马研究及发展公司 | 2017-10-17 | — | — | CN | disclosed |
| CN-107207467-A | 2, 4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG | 癌症研究科技有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-102036967-B | As 5-HT6Arylsulfonyl pyrazoline carboxamidine derivatives as antagonists | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2014-10-15 | — | — | CN | disclosed |
| CN-104003937-A | Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists | ABBOTT HEALTHCARE PRODUCTS BV | 2014-08-27 | — | — | CN | disclosed |
| US-7393849-B2 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7323457-B2 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-20070208008-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | AVENTIS PHARMACEUTICALS INC. (US) | 2007-09-06 | — | — | US | disclosed |
| US-20070191347-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | AVENTIS PHARMACEUTICALS INC. | 2007-08-16 | — | — | US | disclosed |
| US-7223763-B2 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1423373-B1 | SUBSTITUTED AMIDES, SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | AVENTIS PHARMA INC (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040204582-A1 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. | 2004-10-14 | — | — | US | disclosed |
| US-6777577-B2 | ANTICANCER AGENTS; ANTIDIABETIC AGENTS, ANTICHOLESTEROL AGENTS, CARDIOVASCULAR DISORDERS, OSTEOPOROSIS | AVENTIS PHARMACEUTICALS INC. | 2004-08-17 | — | — | US | disclosed |
| US-20030087832-A1 | Substituted amides, sulfonamides and ureas useful for inhibiting kinase activity | AVENTIS PHARMACEUTICALS INC. | 2003-05-08 | — | — | US | disclosed |
| US-20030045480-A1 | Method of treating hyperresorptive bone disorders | ARIAD PHARMACEUTICALS, INC. | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208008-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | CHUK, SRC, DSTYK | HSPB1 2127/4885POLB 3077/4885CA1 2680/4885 |
| US-20040204582-A1 | Substituted sulfonamides and ureas useful for inhibiting kinase activity | CHUK, SRC, DSTYK | HSPB1 1969/4885POLB 3036/4885CA1 2649/4885 |
| US-20260137703-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | EGFR, KRAS, O60361 | HSPB1 1623/4885POLB 458/4885CA1 3692/4885 |
| US-20030045480-A1 | Method of treating hyperresorptive bone disorders | SRC, GRB2, ACP1 | HSPB1 453/4885POLB 4362/4885CA1 3509/4885 |
| US-20070191347-A1 | SUBSTITUTED SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY | CHUK, SRC, DSTYK | HSPB1 2127/4885POLB 3077/4885CA1 2680/4885 |
| US-20030087832-A1 | Substituted amides, sulfonamides and ureas useful for inhibiting kinase activity | SRC, CHUK, DSTYK | HSPB1 2164/4885POLB 3630/4885CA1 2046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.