Water

Water

SCHEMBL28147677

O.O=[N+]([O-])c1ccc(F)cc1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.54
MEN1 known ✓ O00255 2/20 0.51
HSPB1 P04792 4/20 0.72
POLB P06746 1/20 0.64
KCNJ1 P48048 1/20 0.55
KCNH2 Q12809 1/20 0.55
ALDH1A1 P00352 4/20 0.54
HSD17B10 Q99714 1/20 0.54
MAOA P21397 1/20 0.53
MAOB P27338 1/20 0.53
LMNA P02545 2/20 0.52
ALOX12 P18054 2/20 0.51
KMT2A Q03164 2/20 0.51
GAA P10253 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
MAPT P10636 1/20 0.51
PKM P14618 1/20 0.51
HPGD P15428 1/20 0.51
HTT P42858 1/20 0.51
TDP1 Q9NUW8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL536 0.97 HSPB1 (0.75) HSPB1POLBKCNJ1KCNH2ALDH1A1
SCHEMBL7026994 0.97 HSPB1 (0.75) HSPB1POLBKCNJ1KCNH2ALDH1A1
SCHEMBL28001935 0.95 HSPB1 (0.72) HSPB1POLBKCNJ1KCNH2ALDH1A1
Fluoride SCHEMBL4551986 0.95 HSPB1 (0.72) HSPB1POLBKCNJ1KCNH2ALDH1A1
Fluoride SCHEMBL4551988 0.95 HSPB1 (0.72) HSPB1POLBKCNJ1KCNH2ALDH1A1
Water SCHEMBL4218173 0.93 HSPB1 (0.64) HSPB1POLBKCNJ1KCNH2ALDH1A1
Ethylene SCHEMBL27864908 0.92 HSPB1 (0.69) HSPB1POLBKCNJ1KCNH2ALDH1A1
Ethane SCHEMBL28251595 0.92 HSPB1 (0.69) HSPB1POLBKCNJ1KCNH2ALDH1A1
Formaldehyde SCHEMBL28237406 0.92 HSPB1 (0.69) HSPB1POLBKCNJ1KCNH2ALDH1A1
Methyl Alcohol SCHEMBL28785209 0.90 HSPB1 (0.67) HSPB1POLBKCNJ1KCNH2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107004731-A Luminescent solar concentrator comprising disubstituted benzoheterodiazole compounds 艾尼股份公司 2017-08-01 CN disclosed
CN-106748830-A A kind of preparation method of the fluorophenol of 3 amino 4 金凯(辽宁)化工有限公司 2017-05-31 CN disclosed