Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 4/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL4551988 | 1.00 | HSPB1 (0.72) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| SCHEMBL7026994 | 0.97 | HSPB1 (0.75) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| SCHEMBL536 | 0.97 | HSPB1 (0.75) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| SCHEMBL28001935 | 0.95 | HSPB1 (0.72) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| Water SCHEMBL28147677 | 0.95 | HSPB1 (0.72) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| Ethylene SCHEMBL27864908 | 0.92 | HSPB1 (0.69) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| Ethane SCHEMBL28251595 | 0.92 | HSPB1 (0.69) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| Formaldehyde SCHEMBL28237406 | 0.92 | HSPB1 (0.69) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| Methyl Alcohol SCHEMBL28785209 | 0.90 | HSPB1 (0.67) | HSPB1POLBKCNJ1KCNH2ALDH1A1 | |
| SCHEMBL2961612 | 0.90 | HSPB1 (0.67) | HSPB1POLBKCNJ1KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318523-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318523-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS | PTGER4, PTGER3, HTR4 | HSPB1 3700/4885POLB 4455/4885KCNJ1 3612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.