Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | UMPS | P11172 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribose (Furanose) SCHEMBL9616546 | 0.89 | LMNA (0.42) | LMNASMN1; SMN2ALDH1A1MTORTHRB | |
| SCHEMBL5369246 | 0.82 | P2RY14 (0.39) | ALDH1A1ADORA1 | |
| Ribose (Furanose) SCHEMBL5798254 | 0.80 | KDM4E (0.42) | LMNASMN1; SMN2ALDH1A1MTORTHRB | |
| SCHEMBL27614390 | 0.78 | UMPS (0.48) | LMNASMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL8561 | 0.77 | — | — | |
| Ribose (Furanose) SCHEMBL142622 | 0.77 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MTORTHRB | |
| Ribose (Furanose) SCHEMBL8833 | 0.77 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MTORTHRB | |
| Ribose (Furanose) SCHEMBL2325834 | 0.77 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MTORTHRB | |
| Ribose (Furanose) SCHEMBL3341287 | 0.77 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MTORTHRB | |
| Ribose (Furanose) SCHEMBL3673370 | 0.76 | KDM4E (0.44) | LMNASMN1; SMN2ALDH1A1MTORPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300298-A1 | Honokiol Derivates For the Treatment of Proliferative Disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| EP-1853539-A2 | HONOKIOL DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Arbiser, Jack (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006107451-A2 | HONOKIOL DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | UNIV EMORY (US) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300298-A1 | Honokiol Derivates For the Treatment of Proliferative Disorders | CCNK, CDK3, CCNO | LMNA 921/4885SMN1; SMN2 1535/4885ALDH1A1 1982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.