Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | UMPS | P11172 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribose (Furanose) SCHEMBL4576206 | 0.76 | LMNA (0.42) | KDM4ETP53TDP1MAPTLMNA | |
| Ribose (Furanose) SCHEMBL4083935 | 0.74 | LMNA (0.40) | TP53MAPTLMNASMN1; SMN2ALDH1A1 | |
| Ribose (Furanose) SCHEMBL164883 | 0.73 | KDM4E (0.50) | KDM4ETP53TDP1MAPTLMNA | |
| Ribose (Furanose) SCHEMBL1040051 | 0.73 | KDM4E (0.50) | KDM4ETP53TDP1MAPTLMNA | |
| Ribose (Furanose) SCHEMBL218015 | 0.73 | GDA (0.59) | KDM4ETP53TDP1MAPTLMNA | |
| SCHEMBL8332561 | 0.71 | PYGL (0.61) | KDM4EMAPTLMNASMN1; SMN2TSHR | |
| SCHEMBL1814865 | 0.71 | PYGL (0.61) | KDM4EMAPTLMNASMN1; SMN2TSHR | |
| Ribose (Furanose) SCHEMBL3681658 | 0.71 | LMNA (0.43) | KDM4ETP53TDP1MAPTLMNA | |
| Ribose (Furanose) SCHEMBL5798254 | 0.71 | KDM4E (0.42) | KDM4ETP53TDP1MAPTLMNA | |
| Ribose (Furanose) SCHEMBL28792915 | 0.70 | SMN1; SMN2 (0.50) | KDM4ETP53TDP1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9173892-B2 | Acadesine derivatives, products and compositions including same, therapeutic uses thereof, and methods for synthesizing same | UNIVERSITE NICE SOPHIA ANTIPOLIS (FR) | 2015-11-03 | — | — | US | disclosed |
| EP-2699240-B1 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPEUTIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | UNIVERSITÉ NICE SOPHIA ANTIPOLIS (FR) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014143659-A1 | IRREVERSIBLE COVALENT INHIBITORS OF THE GTPASE K-RAS G12C | ARAXES PHARMA LLC (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20140179626-A1 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPUETIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (FR) | 2014-06-26 | — | — | US | disclosed |
| EP-2699240-A2 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPEUTIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | Université Nice Sophia Antipolis (FR) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143624-A2 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPEUTIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | UNIVERSITE NICE SOPHIA ANTIPOLIS (FR) | 2012-10-26 | — | — | WO | disclosed |
| US-20100004156-A1 | Small Compounds That Correct Protein Misfolding and Uses Thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2010-01-07 | — | — | US | disclosed |
| US-20050002943-A1 | Amp-kinase agonists or adenosine pro-drugs as immuno-stimulating agents | UNIVERSITE LIBRE DE BRUXELLES (BE) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179626-A1 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPUETIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | MCL1, ALOX15, ALOX12 | KDM4E 2715/4885TP53 1027/4885TDP1 3861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.