Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | ACE | P12821 | 7/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576379 | 1.00 | PPARG (0.35) | PPARGPPARAACEPPARDMME | |
| SCHEMBL11198946 | 0.88 | ACE (0.47) | PPARGPPARAACEMMEACE2 | |
| SCHEMBL11333699 | 0.88 | PPARG (0.33) | PPARGPPARAACEPPARDMME | |
| SCHEMBL8582126 | 0.86 | MAPT (0.48) | PPARGPPARAACE | |
| SCHEMBL8416392 | 0.83 | ITGB1 (0.44) | PPARGPPARAACEMMEACE2 | |
| SCHEMBL11333708 | 0.82 | ACE (0.34) | PPARGPPARAACEMMEACE2 | |
| SCHEMBL31676720 | 0.81 | MAPT (0.38) | PPARGPPARAACEPPARD | |
| SCHEMBL18954453 | 0.80 | PPARA (0.55) | PPARGPPARAACEPPARD | |
| SCHEMBL8417827 | 0.77 | MAPT (0.47) | ACEMMEACE2 | |
| SCHEMBL1349241 | 0.75 | POLB (0.40) | ACEMMEACE2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5284872-A | Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof | SCHWARZ PHARMA AG (DE) | 1994-02-08 | — | — | US | claimed |
| EP-1414432-A4 | METHODS OF USE FOR NOVEL SULFUR CONTAINING ORGANIC NITRATE COMPOUNDS | NITROMED INC (US) | 2008-01-09 | — | — | EP | disclosed |
| US-20040152753-A1 | Methods of use for novel sulfur containing organic nitrate compounds | NITROMED, INC. | 2004-08-05 | — | — | US | disclosed |
| EP-1414432-A2 | METHODS OF USE FOR NOVEL SULFUR CONTAINING ORGANIC NITRATE COMPOUNDS | Nitromed, Inc. (US) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003013432-A2 | METHODS OF USE FOR NOVEL SULFUR CONTAINING ORGANIC NITRATE COMPOUNDS | NITROMED, INC. (US) | 2003-02-20 | — | — | WO | disclosed |
| US-5705527-A | VASODILATORS AND ANGINA PECTORIS | SANKYO COMPANY, LIMITED (JP) | 1998-01-06 | — | — | US | disclosed |
| EP-0641769-B1 | AMINO ACID DERIVATIVE | SANKYO CO (JP) | 1997-01-29 | — | — | EP | disclosed |
| EP-0451760-B1 | Nitrato alkanoic acid derivatives and method for their production | SANOL ARZNEI SCHWARZ GMBH (DE) | 1995-09-13 | — | — | EP | disclosed |
| EP-0641769-A1 | AMINO ACID DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-5284872-A | Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof | SCHWARZ PHARMA AG (DE) | 1994-02-08 | — | — | US | disclosed |
| EP-0451760-A1 | Nitrato alkanoic acid derivatives and method for their production | SCHWARZ PHARMA AG (DE) | 1991-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152753-A1 | Methods of use for novel sulfur containing organic nitrate compounds | PTGS2, NOS2, PTGS1 | PPARG 892/4885PPARA 1140/4885ACE 2020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.