Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1053081 | 0.86 | MTNR1A (0.69) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3446802 | 0.82 | MTNR1A (0.73) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29639804 | 0.81 | L3MBTL1 (0.70) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13381586 | 0.80 | MEN1 (0.75) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3549720 | 0.80 | L3MBTL1 (0.64) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL698008 | 0.80 | MTNR1A (0.71) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7428200 | 0.79 | HPGD (0.61) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6804590 | 0.79 | MTNR1A (0.59) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL885015 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10310294 | 0.79 | MTNR1A (0.59) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673085-A4 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2008-12-10 | — | — | EP | claimed |
| US-20080166359-A1 | Methods of using MEK inhibitors | EXELIXIS, INC. | 2008-07-10 | — | — | US | claimed |
| EP-1673085-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-06-28 | — | — | EP | claimed |
| WO-2005030140-A2 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-04-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080166359-A1 | Methods of using MEK inhibitors | BRAF, NRAS, KRAS | MTNR1A 3690/4885MTNR1B 3481/4885RAB9A 1196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.