Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5584368 | 0.87 | — | — | |
| SCHEMBL15063634 | 0.83 | ALDH1A1 (0.46) | ALDH1A1MAPK1NPC1NFKB1RAB9A | |
| SCHEMBL15063736 | 0.79 | BCL2L1 (0.35) | CYP1A2CYP3A4BCL2L1NPC1RAB9A | |
| SCHEMBL15063844 | 0.79 | ALDH1A1 (0.40) | ALDH1A1TDP1HSD17B10NPC1RAB9A | |
| SCHEMBL15063814 | 0.79 | CYP1A2 (0.42) | ALDH1A1CYP1A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15063561 | 0.79 | — | — | |
| SCHEMBL15063620 | 0.79 | RAB9A (0.41) | ALDH1A1MAPK1CYP1A2HSD17B10NPC1 | |
| SCHEMBL15064041 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPK1TDP1HSD17B10NPC1 | |
| SCHEMBL15064180 | 0.76 | TAAR1 (0.48) | TAAR1CYP3A4RELAPTPN1NOTUM | |
| SCHEMBL15063939 | 0.76 | ESR2 (0.47) | TAAR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102408380-B | 5-aminopyrimidine-thione compounds and preparation method thereof | UNIV ZHEJIANG | 2014-04-16 | — | — | CN | claimed |
| CN-102408380-A | 5-aminopyrimidine thioketone compound and preparation method thereof | UNIV ZHEJIANG | 2012-04-11 | — | — | CN | claimed |
| EP-3045450-B1 | INTERMEDIATE COMPOUNDS IN PROCESSES FOR PRODUCING PYRIDAZINONE COMPOUNDS | SUMITOMO CHEMICAL CO (JP) | 2018-02-07 | — | — | EP | disclosed |
| EP-3045450-A1 | INTERMEDIATE COMPOUNDS IN A PROCESS FOR PRODUCING PYRIDAZINONE COMPOUNDS | SUMITOMO CHEMICAL CO., LTD. (JP) | 2016-07-20 | — | — | EP | disclosed |
| EP-2614053-B1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATES THEREOF | SUMITOMO CHEMICAL CO (JP) | 2016-03-23 | — | — | EP | disclosed |
| US-9040709-B2 | Method for producing pyridazinone compounds and intermediate thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-05-26 | — | — | US | disclosed |
| US-20140378688-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2014-12-25 | — | — | US | disclosed |
| US-8884010-B2 | Method for producing pyridazinone compounds and intermediate thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-11-11 | — | — | US | disclosed |
| CN-102408380-B | 5-aminopyrimidine-thione compounds and preparation method thereof | UNIV ZHEJIANG | 2014-04-16 | — | — | CN | disclosed |
| CN-102260131-B | Method for mirror selective addition of alkenones | NAT UNIV TSING HUA | 2013-11-06 | — | — | CN | disclosed |
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| US-20130172556-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-07-04 | — | — | US | disclosed |
| CN-102408380-A | 5-aminopyrimidine thioketone compound and preparation method thereof | UNIV ZHEJIANG | 2012-04-11 | — | — | CN | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |
| CN-102260131-A | Method for mirror selective addition of alkenones | — | 2011-11-30 | — | — | CN | disclosed |
| CN-100391943-C | Prepn. of 3-position substituted indole derivative | UNIV ZHEJIANG (CN) | 2008-06-04 | — | — | CN | disclosed |
| CN-1834089-A | Prepn. of 3-position substituted indole derivative | UNIV ZHEJIANG (CN) | 2006-09-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172556-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | PDXK, DHPS, NQO1 | ALDH1A1 482/4885MAPK1 3269/4885TAAR1 2943/4885 |
| US-20140378688-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | PDXK, DHPS, NQO1 | ALDH1A1 482/4885MAPK1 3269/4885TAAR1 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.