Adenine

Adenine

SCHEMBL4579285

Nc1cc[nH]c(=O)n1.Nc1ncnc2[nH]cnc12.Nc1ncnc2[nH]cnc12

nearest known ligand 0.41

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Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 2/20 0.41
PI4KA P42356 2/20 0.34
PI4K2B Q8TCG2 2/20 0.34
PI4K2A Q9BTU6 2/20 0.34
PI4KB Q9UBF8 2/20 0.34
LMNA P02545 1/20 0.34
DRD3 P35462 1/20 0.34
XDH P47989 1/20 0.34
LRRK2 Q5S007 1/20 0.34
PNP P00491 1/20 0.34
PARP1 P09874 1/20 0.33
DYRK1A Q13627 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adenine SCHEMBL19974438 1.00 MAP4K4 (0.41) MAP4K4PI4KAPI4K2BPI4K2API4KB
Adenine SCHEMBL1065182 1.00 MAP4K4 (0.41) MAP4K4PI4KAPI4K2BPI4K2API4KB
Guanine SCHEMBL1730016 0.89 DYRK1A (0.42) MAP4K4LMNAXDHPNPPARP1
Adenine SCHEMBL4579096 0.85 ATAD2 (0.41) MAP4K4PNPPARP1
2,6-Diaminopurine SCHEMBL23292803 0.84 DYRK1A (0.38) MAP4K4LMNAPNPDYRK1A
Guanine SCHEMBL2636585 0.82 KDM4E (0.38) MAP4K4LMNAPNPDYRK1A
Cytosine SCHEMBL15271432 0.81 PNP (0.32) MAP4K4LRRK2PNPPARP1DYRK1A
Adenine SCHEMBL6227731 0.80 ATAD2 (0.37) MAP4K4
Adenine SCHEMBL3416954 0.80 PI4KA (0.48) MAP4K4PI4KAPI4K2BPI4K2API4KB
Adenine SCHEMBL3414603 0.80 PI4KA (0.48) MAP4K4PI4KAPI4K2BPI4K2API4KB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7319026-B2 Amino acid-producing bacteria and a process for preparing L-amino acids DEGUSSA AG (DE) 2008-01-15 US disclosed
EP-1481075-A2 AMINO ACID-PRODUCING BACTERIA AND A PROCESS FOR PREPARING L-AMINO ACIDS Degussa AG (DE) 2004-12-01 EP disclosed
US-20040082040-A1 Amino acid-producing bacteria and a process for preparing L-amino acids DEGUSSA AG 2004-04-29 US disclosed
WO-2003074719-A2 AMINO ACID-PRODUCING BACTERIA AND A PROCESS FOR PREPARING L-AMINO ACIDS DEGUSSA AG (DE) 2003-09-12 WO disclosed