Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 9/20 | 0.39 |
| ▸ | RAB9A | P51151 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.39 |
| ▸ | RELA | Q04206 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726817 | 0.83 | TRPV1 (0.43) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL24305261 | 0.79 | CA12 (0.41) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL10627376 | 0.78 | TRPV1 (0.47) | ALDH1A1SMN1; SMN2MAPTTRPV1TP53 | |
| SCHEMBL18427177 | 0.76 | KIF11 (0.39) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL18408971 | 0.76 | NPC1 (0.42) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL14817234 | 0.74 | TRPV1 (0.36) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL14817232 | 0.74 | TRPV1 (0.36) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL2387705 | 0.74 | PNMT (0.44) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL18610641 | 0.73 | CNR2 (0.40) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL31294407 | 0.73 | ALDH1A1 (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910338-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM, LLC (BM) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009120-A2 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS | IRM LLC (BM) | 2007-01-18 | — | — | WO | disclosed |