Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11368826 | 0.92 | CNR2 (0.44) | NPC1CNR2RORCHSD17B3F2 | |
| SCHEMBL27773420 | 0.89 | L3MBTL1 (0.50) | NPC1L3MBTL1HSD17B3STSHTR7 | |
| SCHEMBL1502354 | 0.86 | ALDH1A1 (0.43) | NPC1L3MBTL1CNR2HSD17B3STS | |
| SCHEMBL1502458 | 0.84 | NPC1 (0.38) | NPC1L3MBTL1HSD17B3STSHTR7 | |
| SCHEMBL27794719 | 0.82 | NPC1 (0.43) | NPC1L3MBTL1HSD17B3STSHTR7 | |
| SCHEMBL13525526 | 0.81 | NPC1 (0.42) | NPC1L3MBTL1HSD17B3HTR7MAPT | |
| SCHEMBL1502488 | 0.81 | NPC1 (0.42) | NPC1L3MBTL1HSD17B3HTR7MAPT | |
| SCHEMBL7038376 | 0.81 | RORC (0.40) | NPC1CNR2RORCHSD17B3STS | |
| SCHEMBL24172235 | 0.80 | GSK3B (0.51) | NPC1CNR2RORCF2F10 | |
| SCHEMBL3671755 | 0.80 | MAPT (0.47) | NPC1L3MBTL1HSD17B3STSHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114773386-B | Chiral bidentate ligand, preparation method and application thereof, and preparation method of catalyst and fexofenadine hydrochloride intermediate | 江苏医药职业学院 | 2023-06-23 | — | — | CN | claimed |
| CN-114773386-A | Chiral bidentate ligand, preparation method and application thereof, and preparation method of catalyst and fexofenadine hydrochloride intermediate | 江苏医药职业学院 | 2022-07-22 | — | — | CN | claimed |
| CN-103333100-B | A kind of synthesis technique of fexofenadine hydrochloride | Chizhou Dongsheng Pharmaceutical Co., Ltd. (CN) | 2016-04-06 | — | — | CN | claimed |
| CN-103333100-A | Synthetic process of fexofenadine hydrochloride | CHIZHOU DONGSHENG PHARMACEUTICAL CO LTD | 2013-10-02 | — | — | CN | claimed |
| CN-115427405-B | Tricyclic compounds, preparation method and medical application thereof | 合肥医工医药股份有限公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114773386-B | Chiral bidentate ligand, preparation method and application thereof, and preparation method of catalyst and fexofenadine hydrochloride intermediate | 江苏医药职业学院 | 2023-06-23 | — | — | CN | disclosed |
| EP-4177248-A1 | A CLASS OF TRICYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | Hefei Institute of Pharmaceutical Industry Co., Ltd. (CN) | 2023-05-10 | — | — | EP | disclosed |
| EP-4177248-A1 | A CLASS OF TRICYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | Hefei Institute of Pharmaceutical Industry Co., Ltd. (CN) | 2023-05-10 | — | — | EP | disclosed |
| US-20230140276-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF | HEFEI AMVITE PHARMACEUTICAL CO., LTD. (CN) | 2023-05-04 | — | — | US | disclosed |
| US-20230140276-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF | HEFEI AMVITE PHARMACEUTICAL CO., LTD. (CN) | 2023-05-04 | — | — | US | disclosed |
| US-20230140276-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF | HEFEI AMVITE PHARMACEUTICAL CO., LTD. (CN) | 2023-05-04 | — | — | US | disclosed |
| CN-115427405-A | Tricyclic compound, preparation method and medical application thereof | 合肥医工医药股份有限公司 | 2022-12-02 | — | — | CN | disclosed |
| EP-0703902-A1 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | ALBANY MOLECULAR RESEARCH, INC. (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1995000482-A1 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | ALBANY MOLECULAR RESEARCH, INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| WO-1989012443-A1 | NOVEL DIBENZO-CYCLOHEPTENYL, -CYCLOHEPTYL AND -OXEPINYL AMINES HAVING ANTIHISTAMINIC PROPERTIES | FISONS CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347123-A2 | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties | FISONS CORPORATION (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4285957-A | ANTIALLERGENS; ANTIHISTAMINES; BRONCHODILATOR AGENTS | RICHARDSON-MERRELL INC. (US) | 1981-08-25 | — | — | US | disclosed |
| US-4285958-A | ANTIALLERGENS; ANTIHISTAMINES; BRONCHODILATOR AGENTS | RICHARDSON-MERRELL INC. (US) | 1981-08-25 | — | — | US | disclosed |
| US-4254130-A | ANTIALLERGENS | RICHARDSON-MERRELL INC. (US) | 1981-03-03 | — | — | US | disclosed |
| US-4254129-A | ANTIALLERGENS, BRONCHODILATORS, ANTIHISTAMINES; 4-DIPHENYLMETHYL PIPERIDINO-ALKANOLS | RICHARDSON-MERRELL INC. (US) | 1981-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230140276-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF | HNMT, CHRM1, HRH4 | NPC1 649/4885L3MBTL1 3564/4885CNR2 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.