Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | MELK | Q14680 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8239665 | 0.94 | AKT1 (0.58) | AKT1MAP3K5ROCK2DYRK1AMAP4K4 | |
| SCHEMBL4582358 | 0.84 | MAP3K5 (0.49) | AKT1MAP3K5ROCK2DYRK1AMAP4K4 | |
| SCHEMBL8241818 | 0.79 | AKT1 (0.60) | AKT1ROCK2DYRK1AMAP4K4MELK | |
| SCHEMBL8244311 | 0.79 | AKT1 (0.65) | AKT1MAP3K5ROCK2DYRK1AMAP4K4 | |
| SCHEMBL4582970 | 0.77 | MAP3K5 (0.39) | AKT1MAP3K5ROCK2DYRK1AMAP4K4 | |
| SCHEMBL8235518 | 0.76 | AKT1 (0.77) | AKT1ROCK2DYRK1AMAP4K4MELK | |
| SCHEMBL4583788 | 0.74 | AKT1 (0.46) | AKT1MAP3K5ROCK2DYRK1AMAP4K4 | |
| SCHEMBL4584368 | 0.74 | AKT1 (0.59) | AKT1MAP3K5MAPK14GSK3BAKT3 | |
| SCHEMBL13887987 | 0.72 | ROCK1 (0.64) | AKT1DYRK1AGSK3BRPS6KA5PRKCG | |
| SCHEMBL4582789 | 0.72 | AKT1 (0.64) | AKT1ROCK2DYRK1AMAP4K4MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |