Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.35 |
| ▸ | CDC7 | O00311 | 4/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | PRKACA | P17612 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.34 |
| ▸ | MELK | Q14680 | 3/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.34 |
| ▸ | CDK8 | P49336 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | CIT | O14578 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582358 | 0.87 | MAP3K5 (0.49) | MAP3K5AKT1ROCK1CDC7ROCK2 | |
| SCHEMBL4583788 | 0.78 | AKT1 (0.46) | MAP3K5AKT1ROCK1CDC7ROCK2 | |
| SCHEMBL8239665 | 0.78 | AKT1 (0.58) | MAP3K5AKT1ROCK1CDC7ROCK2 | |
| SCHEMBL4582334 | 0.77 | AKT1 (0.51) | MAP3K5AKT1ROCK1CDC7ROCK2 | |
| SCHEMBL4584397 | 0.75 | AKT1 (0.37) | MAP3K5AKT1ROCK1CITMAPK14 | |
| SCHEMBL8240780 | 0.74 | AKT1 (0.44) | MAP3K5AKT1ROCK1CDC7ROCK2 | |
| SCHEMBL4584368 | 0.73 | AKT1 (0.59) | MAP3K5AKT1ROCK1PIM1GSK3B | |
| SCHEMBL1529833 | 0.69 | HDAC8 (0.40) | AKT1 | |
| SCHEMBL8239835 | 0.68 | DYRK1A (0.40) | AKT1ROCK1CDC7ROCK2PRKACA | |
| SCHEMBL8234027 | 0.67 | AKT1 (0.57) | AKT1ROCK1CDC7ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |