Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 10/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.40 |
| ▸ | AKT2 | P31751 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | CIT | O14578 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MELK | Q14680 | 2/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583788 | 0.91 | AKT1 (0.46) | MAP3K5AKT1AKT3AKT2ROCK1 | |
| SCHEMBL8239665 | 0.87 | AKT1 (0.58) | MAP3K5AKT1AKT3AKT2ROCK1 | |
| SCHEMBL4582970 | 0.87 | MAP3K5 (0.39) | MAP3K5AKT1AKT3ROCK1CIT | |
| SCHEMBL8240780 | 0.87 | AKT1 (0.44) | MAP3K5AKT1AKT3AKT2ROCK1 | |
| SCHEMBL4584397 | 0.85 | AKT1 (0.37) | MAP3K5AKT1AKT3AKT2ROCK1 | |
| SCHEMBL4582334 | 0.84 | AKT1 (0.51) | MAP3K5AKT1AKT3AKT2ROCK1 | |
| SCHEMBL4584368 | 0.82 | AKT1 (0.59) | MAP3K5AKT1AKT3AKT2ROCK1 | |
| SCHEMBL8234027 | 0.79 | AKT1 (0.57) | AKT1AKT3ROCK1CITCDK8 | |
| SCHEMBL8241935 | 0.74 | AKT1 (0.75) | AKT1AKT3AKT2ROCK1MAPK14 | |
| SCHEMBL8239835 | 0.71 | DYRK1A (0.40) | AKT1AKT3ROCK1DYRK1AMELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |