Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 3/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CIT | O14578 | 3/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | F3 | P13726 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582358 | 0.85 | MAP3K5 (0.49) | AKT1MAP3K5AKT2AKT3CSNK1A1 | |
| SCHEMBL4583788 | 0.76 | AKT1 (0.46) | AKT1MAP3K5AKT2AKT3CSNK1A1 | |
| SCHEMBL4582970 | 0.75 | MAP3K5 (0.39) | AKT1MAP3K5AKT3CSNK1A1CSNK1D | |
| SCHEMBL8239665 | 0.73 | AKT1 (0.58) | AKT1MAP3K5AKT2AKT3CSNK1D | |
| SCHEMBL8240780 | 0.72 | AKT1 (0.44) | AKT1MAP3K5AKT2AKT3CSNK1A1 | |
| SCHEMBL4582334 | 0.70 | AKT1 (0.51) | AKT1MAP3K5AKT2AKT3CSNK1D | |
| SCHEMBL8241935 | 0.68 | AKT1 (0.75) | AKT1AKT2AKT3ROCK1MAPK14 | |
| SCHEMBL4584368 | 0.68 | AKT1 (0.59) | AKT1MAP3K5AKT2AKT3ROCK1 | |
| SCHEMBL8234027 | 0.68 | AKT1 (0.57) | AKT1AKT3CSNK1A1CSNK1DROCK1 | |
| SCHEMBL8240317 | 0.67 | AKT1 (0.45) | AKT1MAP3K5ROCK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |