Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377187 | 0.83 | DPP4 (0.43) | MAPTKMT2AALDH1A1 | |
| SCHEMBL4373941 | 0.83 | DPP4 (0.43) | MAPTKMT2AALDH1A1 | |
| SCHEMBL4380602 | 0.82 | PRCP (0.41) | CNR2CNR1KMT2ACYP3A4MEN1 | |
| SCHEMBL4371626 | 0.82 | ALDH1A1 (0.38) | CNR2NPC1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL3777012 | 0.74 | LDHA (0.49) | KMT2AALDH1A1ACACB | |
| SCHEMBL1442862 | 0.74 | GPR88 (0.48) | NPSR1CNR2RAB9AKMT2AALDH1A1 | |
| SCHEMBL1673387 | 0.73 | NPSR1 (0.47) | NPSR1CNR2KMT2AALDH1A1CYP3A4 | |
| SCHEMBL6831820 | 0.73 | LDHA (0.49) | NPSR1RAB9ANPC1MAPTPAX8 | |
| SCHEMBL6046226 | 0.73 | SLC1A3 (0.51) | NPSR1RAB9ANPC1MAPTPAX8 | |
| SCHEMBL17334054 | 0.73 | ACACB (0.62) | NPSR1RAB9ACNR1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |