Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 6/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377187 | 0.85 | DPP4 (0.43) | KMT2ALMNA | |
| SCHEMBL4373941 | 0.85 | DPP4 (0.43) | KMT2ALMNA | |
| SCHEMBL4371626 | 0.84 | ALDH1A1 (0.38) | CYP2C9MEN1CYP2D6CYP2C19KMT2A | |
| SCHEMBL4371128 | 0.82 | TRPM8 (0.41) | MEN1CYP2C19KMT2ABLM | |
| SCHEMBL4583470 | 0.82 | NPSR1 (0.50) | MEN1KMT2ACNR2CNR1CYP3A4 | |
| SCHEMBL16238974 | 0.77 | PRCP (0.45) | PRCPFFAR2ADRB2CYP2C9MEN1 | |
| SCHEMBL20204169 | 0.77 | PRCP (0.45) | PRCPFFAR2ADRB2CYP2C9MEN1 | |
| SCHEMBL16238971 | 0.77 | PRCP (0.45) | PRCPFFAR2ADRB2CYP2C9MEN1 | |
| SCHEMBL4374417 | 0.76 | ADRB2 (0.40) | ADRB2CYP2D6KMT2ANFKB1BLM | |
| SCHEMBL391064 | 0.76 | CYP2C9 (0.45) | PRCPFFAR2ADRB2CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |