Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | LAP3 | P28838 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456015 | 0.93 | SPHK1 (0.43) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL4582995 | 0.84 | — | — | |
| SCHEMBL721340 | 0.84 | OPRM1 (0.55) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL10751730 | 0.82 | OPRM1 (0.54) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL29007339 | 0.82 | OPRM1 (0.54) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL5702825 | 0.81 | OPRM1 (0.52) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL28004000 | 0.78 | OPRM1 (0.50) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL7565736 | 0.77 | ADH1B (0.47) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL11859135 | 0.77 | SPHK1 (0.45) | SPHK1OPRM1TP53CYP2D6LMNA | |
| SCHEMBL2026328 | 0.76 | OPRM1 (0.43) | SPHK1OPRM1TP53CYP3A4LAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015162459-A1 | AMINO PYRAZINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-10-29 | — | — | WO | disclosed |
| US-20080081870-A1 | Size composition | BAYER MATERIALSCIENCE AG (DE) | 2008-04-03 | — | — | US | disclosed |
| EP-1905788-A2 | Sizing composition | Bayer MaterialScience AG (DE) | 2008-04-02 | — | — | EP | disclosed |
| US-4223138-A | VAPORIZATION, CONDENSATION, RETARDING FLOW TO REACTION ZONE | BAYER AKTIENGESELLSCHAFT (DE) | 1980-09-16 | — | — | US | disclosed |