Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | APAF1 | O14727 | 1/20 | 0.63 |
| ▸ | TDP2 | O95551 | 4/20 | 0.49 |
| ▸ | NSD2 | O96028 | 3/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.46 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.46 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15698467 | 0.88 | S100A4 (0.63) | S100A4ALDH1A1APAF1TDP2NSD2 | |
| SCHEMBL3317054 | 0.83 | APAF1 (0.91) | S100A4ALDH1A1APAF1NSD2MEN1 | |
| SCHEMBL2599332 | 0.81 | S100A4 (0.71) | S100A4ALDH1A1APAF1TDP2NSD2 | |
| SCHEMBL2599211 | 0.81 | S100A4 (1.00) | S100A4ALDH1A1APAF1TDP2NSD2 | |
| SCHEMBL3315349 | 0.79 | ALDH1A1 (0.72) | S100A4ALDH1A1APAF1MAPTSMN1; SMN2 | |
| SCHEMBL30587688 | 0.79 | ALDH1A1 (0.72) | S100A4ALDH1A1APAF1MAPTSMN1; SMN2 | |
| SCHEMBL21814471 | 0.77 | ALDH1A1 (0.70) | S100A4ALDH1A1APAF1MAPTSMN1; SMN2 | |
| SCHEMBL21814443 | 0.77 | ALDH1A1 (0.70) | S100A4ALDH1A1APAF1MAPTSMN1; SMN2 | |
| SCHEMBL21814535 | 0.77 | ALDH1A1 (0.70) | S100A4ALDH1A1APAF1MAPTSMN1; SMN2 | |
| SCHEMBL21814430 | 0.77 | ALDH1A1 (0.70) | S100A4ALDH1A1APAF1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | claimed |
| WO-2010042500-A2 | HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE | EMORY UNIVERSITY (US) | 2010-04-15 | — | — | WO | claimed |
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | EMORY UNIVERSITY (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010042500-A2 | HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE | EMORY UNIVERSITY (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022070-A1 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use | HSP90AB1, HSP90AA1, HSP90AB2P | S100A4 1434/4885ALDH1A1 2606/4885APAF1 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.