Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116228 | 1.00 | MAP4K4 (0.48) | MAP4K4GPR119SUV39H2HDAC1SETD7 | |
| SCHEMBL4573360 | 0.86 | KIT (0.37) | PIK3CDKITGRM1 | |
| SCHEMBL4573909 | 0.86 | MAP4K4 (0.46) | MAP4K4GPR119SUV39H2HDAC1SETD7 | |
| SCHEMBL8108577 | 0.86 | MAP4K4 (0.46) | MAP4K4GPR119SUV39H2HDAC1SETD7 | |
| SCHEMBL8117739 | 0.81 | MAP4K4 (0.52) | MAP4K4GPR119SUV39H2HDAC1SETD7 | |
| SCHEMBL4573401 | 0.81 | MAP4K4 (0.52) | MAP4K4GPR119SUV39H2HDAC1SETD7 | |
| SCHEMBL4584408 | 0.80 | MAP4K4 (0.52) | MAP4K4GPR119SUV39H2HDAC1SETD7 | |
| SCHEMBL8113244 | 0.80 | MAP4K4 (0.52) | MAP4K4GPR119SUV39H2HDAC1SETD7 | |
| SCHEMBL8110534 | 0.78 | CHRM4 (0.53) | MAP4K4GPR119SUV39H2HDAC1NR1H2 | |
| SCHEMBL4584304 | 0.77 | GPR119 (0.52) | MAP4K4GPR119SUV39H2HDAC1SETD7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |