Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 15/20 | 0.52 |
| ▸ | CA1 | P00915 | 12/20 | 0.52 |
| ▸ | CA9 | Q16790 | 11/20 | 0.52 |
| ▸ | CA12 | O43570 | 10/20 | 0.52 |
| ▸ | CA5A | P35218 | 6/20 | 0.52 |
| ▸ | CA7 | P43166 | 6/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.52 |
| ▸ | CA6 | P23280 | 3/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.48 |
| ▸ | CA4 | P22748 | 3/20 | 0.48 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84516 | 0.82 | CA2 (0.68) | ALDH1A1CA2CA1CA9CA12 | |
| Fluoride SCHEMBL28353367 | 0.80 | CA2 (0.66) | ALDH1A1CA2CA1CA9CA12 | |
| Hydrochloric Acid SCHEMBL3532247 | 0.80 | CA2 (0.66) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL1186051 | 0.80 | ALDH1A1 (0.62) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL1790668 | 0.80 | ALDH1A1 (0.62) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL9423733 | 0.80 | CA2 (0.66) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL8248221 | 0.80 | ALDH1A1 (0.62) | ALDH1A1CA2CA1CA9CA12 | |
| Hydrochloric Acid SCHEMBL2352018 | 0.78 | ALDH1A1 (0.60) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL28575526 | 0.78 | ALDH1A1 (0.60) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL12112205 | 0.78 | ALDH1A1 (0.60) | ALDH1A1CA2CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008077651-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | claimed |
| US-8729089-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-31 | — | — | US | disclosed |
| WO-2008077651-A1 | PYRIDO(3,2-D)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, DPYD, PNP | ALDH1A1 1142/4885CA2 4444/4885CA1 4802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.