Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 16/20 | 0.54 |
| ▸ | CA1 | P00915 | 13/20 | 0.54 |
| ▸ | CA9 | Q16790 | 12/20 | 0.54 |
| ▸ | CA12 | O43570 | 10/20 | 0.54 |
| ▸ | CA7 | P43166 | 7/20 | 0.54 |
| ▸ | CA5A | P35218 | 6/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.54 |
| ▸ | CA6 | P23280 | 3/20 | 0.54 |
| ▸ | CA3 | P07451 | 2/20 | 0.54 |
| ▸ | CA4 | P22748 | 4/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186051 | 1.00 | ALDH1A1 (0.62) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL8248221 | 1.00 | ALDH1A1 (0.62) | ALDH1A1CA2CA1CA9CA12 | |
| Hydrochloric Acid SCHEMBL2352018 | 0.98 | ALDH1A1 (0.60) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL24152552 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TSHRADRB2 | |
| SCHEMBL84516 | 0.84 | CA2 (0.68) | ALDH1A1CA2CA1CA9CA12 | |
| Hydrochloric Acid SCHEMBL3532247 | 0.82 | CA2 (0.66) | ALDH1A1CA2CA1CA9CA12 | |
| Fluoride SCHEMBL28353367 | 0.82 | CA2 (0.66) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL14211437 | 0.82 | ENPP2 (0.48) | ALDH1A1ADRB2 | |
| SCHEMBL9423733 | 0.82 | CA2 (0.66) | ALDH1A1CA2CA1CA9CA12 | |
| SCHEMBL8182080 | 0.82 | ENPP2 (0.48) | ALDH1A1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034094-B1 | PHOSPHODIESTERASE INHIBITORS AND USE | ZENSHINE PHARMACEUTICALS NANJING GROUP CO LTD (CN) | 2026-04-15 | — | — | EP | disclosed |
| CN-115151253-B | Phosphodiesterase inhibitors and uses | 南京征祥医药有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-116574099-A | Phosphodiesterase inhibitors and uses | 南京征祥医药有限公司 | 2023-08-11 | — | — | CN | disclosed |
| US-11673889-B2 | Substituted imidazo[4,5-c][1,8]naphthyridines as phosphodiesterase inhibitors | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2023-06-13 | — | — | US | disclosed |
| US-20230014730-A1 | PHOSPHODIESTERASE INHIBITORS AND USE | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2023-01-19 | — | — | US | disclosed |
| CN-115151253-A | Phosphodiesterase inhibitors and uses thereof | 南京征祥医药有限公司 | 2022-10-04 | — | — | CN | disclosed |
| EP-4034094-A1 | PHOSPHODIESTERASE INHIBITORS AND USE | Nanjing Zhengxiang Pharmaceuticals Co., Ltd. (CN) | 2022-08-03 | — | — | EP | disclosed |
| US-20220220114-A1 | PHOSPHODIESTERASE INHIBITORS AND USE | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2022-07-14 | — | — | US | disclosed |
| WO-2021061803-A1 | PHOSPHODIESTERASE INHIBITORS AND USE | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2021-04-01 | — | — | WO | disclosed |
| US-8536187-B2 | 2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536187-B2 | 2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536187-B2 | 2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20110123493-A1 | 2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110123493-A1 | 2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110123493-A1 | 2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| WO-2010002998-A1 | 2,4,6-TRISUBSTITUTED PYRIDO (3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110123493-A1 | 2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, CYP2S1, DPYD | ALDH1A1 732/4885CA2 3079/4885CA1 4693/4885 |
| US-11673889-B2 | Substituted imidazo[4,5-c][1,8]naphthyridines as phosphodiesterase inhibitors | ENPP1, ENPP3, PDE4A | ALDH1A1 518/4885CA2 3011/4885CA1 4735/4885 |
| US-20220220114-A1 | PHOSPHODIESTERASE INHIBITORS AND USE | ENPP1, ENPP3, PDE4A | ALDH1A1 1493/4885CA2 2126/4885CA1 4390/4885 |
| US-20230014730-A1 | PHOSPHODIESTERASE INHIBITORS AND USE | ENPP1, ENPP3, PDE4A | ALDH1A1 1493/4885CA2 2126/4885CA1 4390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.