Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | PREP | P48147 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506148 | 0.84 | MMP13 (0.49) | ADAM10MMP1MMP2MMP3MMP13 | |
| SCHEMBL3506151 | 0.84 | MMP13 (0.49) | ADAM10MMP1MMP2MMP3MMP13 | |
| SCHEMBL14138680 | 0.84 | ADAM10 (0.46) | ADAM10MMP1MMP2MMP3MMP13 | |
| Trifluoroacetic Acid SCHEMBL5100039 | 0.82 | MMP13 (0.47) | ADAM10MMP1MMP2MMP3MMP13 | |
| Trifluoroacetic Acid SCHEMBL5815006 | 0.82 | MMP13 (0.47) | ADAM10MMP1MMP2MMP3MMP13 | |
| SCHEMBL6540255 | 0.79 | DPP4 (0.57) | PREPHRH3RAB9ADPP4ALDH1A1 | |
| SCHEMBL3504779 | 0.74 | NPC1 (0.49) | ADAM10MMP1MMP2MMP3MMP13 | |
| SCHEMBL2986692 | 0.73 | HRH4 (0.44) | ADAM10MMP1MMP2MMP3MMP13 | |
| SCHEMBL1777690 | 0.73 | RAB9A (0.51) | RAB9ASMN1; SMN2POLBMAPTALDH1A1 | |
| SCHEMBL1777692 | 0.73 | RAB9A (0.51) | RAB9ASMN1; SMN2POLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715892-A4 | METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS | CHEMOCENTRYX INC (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1715892-A2 | METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS | ChemoCentryx Inc (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005074645-A2 | METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS | CHEMOCENTRYX, INC. (US) | 2005-08-18 | — | — | WO | disclosed |