Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | HRH2 | P25021 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797540 | 0.72 | ENPP2 (0.50) | TMEM97SIGMAR1HRH1HRH3HTR1A | |
| SCHEMBL12469312 | 0.71 | SLC6A2 (0.46) | SLC6A4MEN1KMT2ACHRM3SLC6A2 | |
| SCHEMBL4239069 | 0.70 | ALDH1A1 (0.53) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL28699149 | 0.70 | TMEM97 (0.77) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL30449380 | 0.70 | TMEM97 (0.77) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL803663 | 0.70 | JAK2 (0.54) | SIGMAR1MEN1KMT2AJAK2JAK1 | |
| SCHEMBL2335192 | 0.70 | HDAC1 (0.42) | MEN1KMT2ADDB1CRBNHDAC1 | |
| SCHEMBL17560116 | 0.70 | TACR1 (0.41) | SLC6A4ENPP2MEN1KMT2ACHRM2 | |
| SCHEMBL21800218 | 0.70 | TMEM97 (0.51) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL29593677 | 0.69 | JAK2 (0.51) | SIGMAR1MEN1KMT2AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |