Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 3/20 | 0.33 |
| ▸ | FEN1 | P39748 | 3/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.33 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546263 | 0.67 | — | — | |
| SCHEMBL9361606 | 0.60 | — | — | |
| SCHEMBL43657 | 0.60 | KDM4E (0.41) | KDM4EERCC1FEN1ERCC4ERCC5 | |
| SCHEMBL1959323 | 0.57 | PAX8 (0.32) | — | |
| SCHEMBL43955 | 0.57 | KDM4E (0.33) | KDM4E | |
| SCHEMBL7900407 | 0.56 | KDM4E (0.94) | KDM4EERCC1FEN1ERCC4ERCC5 | |
| SCHEMBL1025411 | 0.56 | ERCC1 (0.62) | KDM4EERCC1FEN1ERCC4CA12 | |
| SCHEMBL5516639 | 0.56 | CA12 (0.38) | KDM4EERCC1FEN1ERCC4ERCC5 | |
| SCHEMBL1704180 | 0.55 | DBH (0.41) | KDM4ERNASEH1 | |
| SCHEMBL472917 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311255-A4 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | PICOWER INST MED RES (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1311255-A1 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2003-05-21 | — | — | EP | disclosed |
| US-6492428-B1 | MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF); SUBSTITUTED IMINOQUINONE OR ORTHOQUINONE RING SYSTEMS | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH | 2002-12-10 | — | — | US | disclosed |
| WO-2002007720-A1 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2002-01-31 | — | — | WO | disclosed |