SCHEMBL4586415

SCHEMBL4586415

CC(N)CCN1CCC(N(Cc2cccc(C#N)c2)c2ccc([S+](C)[O-])cc2)CC1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 11/20 0.45
KCNH2 Q12809 1/20 0.42
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41
PGR P06401 2/20 0.40
DCUN1D1 Q96GG9 1/20 0.38
F10 P00742 1/20 0.37
DPP4 P27487 1/20 0.36
DPP9 Q86TI2 1/20 0.36
DPP7 Q9UHL4 1/20 0.36
MLNR O43193 1/20 0.36
NOS3 P29474 1/20 0.35
NOS1 P29475 1/20 0.35
NOS2 P35228 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4586071 0.85 KCNH2 (0.52) CCR5KCNH2SLC6A2SLC6A4SLC6A3
SCHEMBL4240430 0.84 CCR5 (0.54) CCR5KCNH2SLC6A2SLC6A4SLC6A3
SCHEMBL4585533 0.84 CCR5 (0.50) CCR5KCNH2SLC6A2SLC6A4SLC6A3
SCHEMBL4586590 0.84 CCR5 (0.47) CCR5KCNH2SLC6A2SLC6A4SLC6A3
SCHEMBL4586343 0.82 CCR5 (0.51) CCR5KCNH2PGRDCUN1D1F10
SCHEMBL4585633 0.82 CCR5 (0.47) CCR5KCNH2SLC6A2SLC6A4SLC6A3
SCHEMBL4586689 0.79 CCR5 (0.51) CCR5KCNH2PGRDCUN1D1F10
SCHEMBL4587068 0.79 CCR5 (0.48) CCR5KCNH2SLC6A2SLC6A4SLC6A3
SCHEMBL4244941 0.77 CCR5 (0.47) CCR5KCNH2PGR
SCHEMBL4248622 0.73 CCR5 (0.85) CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1708703-A4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC (CA) 2008-04-09 EP disclosed
EP-1708703-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2006-10-11 EP disclosed
WO-2005059107-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2005-06-30 WO disclosed