Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240573 | 0.85 | CCR5 (0.56) | CCR5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4585633 | 0.85 | CCR5 (0.47) | CCR5KCNH2F10DCUN1D1SLC6A2 | |
| SCHEMBL4586071 | 0.85 | KCNH2 (0.52) | CCR5KCNH2DCUN1D1SLC6A2SLC6A4 | |
| SCHEMBL4585533 | 0.84 | CCR5 (0.50) | CCR5KCNH2F10DCUN1D1SLC6A2 | |
| SCHEMBL4586415 | 0.84 | CCR5 (0.45) | CCR5KCNH2F10DCUN1D1SLC6A2 | |
| SCHEMBL4586343 | 0.83 | CCR5 (0.51) | CCR5KCNH2F10DCUN1D1PGR | |
| SCHEMBL4244475 | 0.82 | CCR5 (0.54) | CCR5KCNH2F10SLC6A2SLC6A4 | |
| SCHEMBL4244523 | 0.81 | SLC6A2 (0.57) | CCR5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4586689 | 0.80 | CCR5 (0.51) | CCR5KCNH2F10DCUN1D1PGR | |
| SCHEMBL4587068 | 0.79 | CCR5 (0.48) | CCR5KCNH2DCUN1D1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |