SCHEMBL458677

SCHEMBL458677

CCc1cc(C)cc(CC)c1C(=O)C(=O)NNC

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.34
NR1H2 P55055 1/20 0.33
NR1H3 Q13133 1/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
HTT P42858 2/20 0.33
GAA P10253 2/20 0.33
KMT2A Q03164 2/20 0.32
KDM4E B2RXH2 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
NLRP3 Q96P20 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
CYP3A4 P08684 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28089974 0.81 BACE1 (0.33) GAAKMT2AMEN1
SCHEMBL458213 0.80 KDM4E (0.38) ALDH1A1SMN1; SMN2HTTGAAKMT2A
SCHEMBL10288671 0.77 ALDH1A1 (0.32) ALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL469922 0.76 KDM4E (0.33) SMN1; SMN2HTTGAAKDM4EL3MBTL1
SCHEMBL457470 0.75 KDM4E (0.40) ALDH1A1SMN1; SMN2HTTGAAKMT2A
SCHEMBL15341175 0.75 KDM4E (0.36) ALDH1A1SMN1; SMN2HTTGAAKMT2A
SCHEMBL458248 0.74 NR1H2 (0.39) ALDH1A1NR1H2NR1H3SMN1; SMN2HTT
SCHEMBL15063894 0.73 SMN1; SMN2 (0.37) SMN1; SMN2GAAKMT2AKDM4EL3MBTL1
SCHEMBL12503751 0.73 SMN1; SMN2 (0.37) SMN1; SMN2GAAKMT2AKDM4EL3MBTL1
SCHEMBL457973 0.73 KDM4E (0.35) ALDH1A1SMN1; SMN2HTTGAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2614053-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-07-17 EP disclosed
WO-2012033225-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-03-15 WO disclosed