SCHEMBL458248

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL15086651	0.87	NR1H2 (0.42)	NR1H2NR1H3HTTATML3MBTL1
	SCHEMBL7523545	0.82	ALDH1A1 (0.46)	NR1H2NR1H3HTTATML3MBTL1
	SCHEMBL27926223	0.82	HTT (0.35)	NR1H2NR1H3HTTATML3MBTL1
	Phosphine SCHEMBL27473852	0.81	ALDH1A1 (0.45)	NR1H2NR1H3HTTATML3MBTL1
	SCHEMBL457470	0.78	KDM4E (0.40)	HTTL3MBTL1ALDH1A1KDM4ESMN1; SMN2
	SCHEMBL15341175	0.78	KDM4E (0.36)	HTTL3MBTL1ALDH1A1MAPTKDM4E
	SCHEMBL29257749	0.76	NPSR1 (0.47)	NR1H2NR1H3HTTL3MBTL1ALDH1A1
	SCHEMBL457973	0.76	KDM4E (0.35)	HTTL3MBTL1ALDH1A1KDM4ESMN1; SMN2
	SCHEMBL458677	0.74	ALDH1A1 (0.34)	NR1H2NR1H3HTTATML3MBTL1
	SCHEMBL455082	0.73	CA12 (0.44)	HTTATML3MBTL1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.