SCHEMBL4587267

SCHEMBL4587267

[c]1nonc1-c1ccco1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.43
KDM4E B2RXH2 7/20 0.43
HSD17B10 Q99714 5/20 0.43
HPGD P15428 5/20 0.43
POLB P06746 4/20 0.43
MAPT P10636 4/20 0.43
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
BLM P54132 3/20 0.43
PKM P14618 3/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
TDP1 Q9NUW8 3/20 0.43
ALOX15 P16050 2/20 0.43
CASP1 P29466 2/20 0.43
PTPN7 P35236 2/20 0.43
RECQL P46063 2/20 0.43
CASP7 P55210 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
USP2 O75604 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4995016 0.68 MEN1 (0.39) ALDH1A1HPGDMAPTNPC1RAB9A
SCHEMBL570221 0.67 ALDH1A1 (0.46) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL1799678 0.67 ALDH1A1 (0.63) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL577970 0.64 KDM4E (0.56) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL8183045 0.64 ALDH1A1 (0.43) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL1989146 0.63 ALDH1A1 (0.42) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL13528571 0.61 NPC1 (1.00) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL2114343 0.61 MAPT (1.00) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL353240 0.61 ALDH1A1 (0.45) ALDH1A1KDM4EHSD17B10HPGDPOLB
SCHEMBL1036366 0.61 ALDH1A1 (0.45) ALDH1A1KDM4EHSD17B10HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879604-B1 PIF TETRAPEPTIDES BIOINCEPT LLC (US) 2020-06-03 EP disclosed
EP-3655010-A2 PEPTIDES AND METHODS OF TRANSPLANTATION AND RESTORATIVE ORGAN FUNCTION Bioincept LLC (US) 2020-05-27 EP disclosed
WO-2019018447-A2 PEPTIDES AND METHODS OF TRANSPLANTATION AND RESTORATIVE ORGAN FUNCTION BIOINCEPT, LLC (US) 2019-01-24 WO disclosed
EP-3377085-A1 PEPTIDES AND METHODS OF TREATING ENDOMETRIOSIS USING THE SAME Bioincept, LLC. (US) 2018-09-26 EP disclosed
WO-2018156801-A2 PEPTIDES AND METHODS OF TREATING DYSTROPHY-RELATED DISORDERS USING THE SAME BIOINCEPT, LLC (US) 2018-08-30 WO disclosed
EP-3341739-A1 MUTANT PEPTIDES AND METHODS OF TREATING SUBJECTS USING THE SAME BioIncept LLC (US) 2018-07-04 EP disclosed
EP-3341006-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODAMAGE BioIncept LLC (US) 2018-07-04 EP disclosed
US-20170336406-A1 PIF BINDING AS A MARKER FOR IMMUNE DYSREGULATION BIOINCEPT, LLC (US) 2017-11-23 US disclosed
US-20170319645-A1 COMPOSITIONS AND METHODS FOR TREATING ACUTE RADIATION SYNDROME BIOINCEPT, LLC (US) 2017-11-09 US disclosed
EP-3215847-A1 PIF BINDING AS A MARKER FOR IMMUNE DYSREGULATION Bioincept LLC (US) 2017-09-13 EP disclosed
WO-2017079430-A1 PEPTIDES AND METHODS OF TREATING ENDOMETRIOSIS USING THE SAME BIOINCEPT, LLC (US) 2017-05-11 WO disclosed
WO-2017039751-A1 MUTANT PEPTIDES AND METHODS OF TREATING SUBJECTS USING THE SAME BIOINCEPT, LLC (US) 2017-03-09 WO disclosed
WO-2017040186-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODAMAGE BIOINCEPT, LLC (US) 2017-03-09 WO disclosed
WO-2016073513-A1 PIF BINDING AS A MARKER FOR IMMUNE DYSREGULATION BIOINCEPT, LLC (US) 2016-05-12 WO disclosed
EP-1680442-A4 PIF PEPTIDES BIOLOGIC ACTIVITIES, SITE OF ACTION, AND THE ANTIBODY TO DETECT PIF BIOINCEPT LLC (US) 2008-04-09 EP disclosed
EP-1898942-A2 ANTIPROLIFERATIVE PEPTIDES AND ANTIBODIES FOR THEIR DETECTION Biospectrum, Inc. (US) 2008-03-19 EP disclosed
WO-2007129999-A2 ANTIPROLIFERATIVE PEPTIDES AND ANTIBODIES FOR THEIR DETECTION BIOSPECTRUM, INC. (US) 2007-11-15 WO disclosed
EP-1680442-A2 PIF PEPTIDES BIOLOGIC ACTIVITIES, SITE OF ACTION, AND THE ANTIBODY TO DETECT PIF Bioincept, LLC. (US) 2006-07-19 EP disclosed
WO-2005040196-A2 PIF PEPTIDES BIOLOGIC ACTIVITIES, SITE OF ACTION, AND THE ANTIBODY TO DETECT PIF BIOINCEPT, LLC (US) 2005-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170336406-A1 PIF BINDING AS A MARKER FOR IMMUNE DYSREGULATION MIF, PGF, IRF2BP2 ALDH1A1 2488/4885KDM4E 2968/4885HSD17B10 3518/4885
US-20170319645-A1 COMPOSITIONS AND METHODS FOR TREATING ACUTE RADIATION SYNDROME FLT3, IGFBP1, CXCL12 ALDH1A1 2375/4885KDM4E 4667/4885HSD17B10 4560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.