Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.44 |
| ▸ | KHK | P50053 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4588676 | 1.00 | MAPT (0.47) | MAPTBCL2A1KHKALDH1A1LMNA | |
| SCHEMBL22796057 | 0.78 | JAK3 (0.47) | MAPTALDH1A1HRH3 | |
| SCHEMBL20157184 | 0.78 | MAPT (0.46) | MAPTBCL2A1KHKALDH1A1LMNA | |
| SCHEMBL23759875 | 0.77 | ADRB1 (0.51) | ALDH1A1HTR2C | |
| SCHEMBL20157447 | 0.77 | MAPT (0.45) | MAPTBCL2A1KHKHRH4 | |
| SCHEMBL31463645 | 0.77 | ATM (0.45) | HRH3 | |
| SCHEMBL12892626 | 0.74 | HTR3E (0.61) | MAPTBCL2A1KHKALDH1A1LMNA | |
| SCHEMBL2245201 | 0.74 | HTR3E (0.61) | MAPTBCL2A1KHKALDH1A1LMNA | |
| SCHEMBL4240000 | 0.74 | HTR3E (0.61) | MAPTBCL2A1KHKALDH1A1LMNA | |
| SCHEMBL30208090 | 0.74 | HTR3E (0.61) | MAPTBCL2A1KHKALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |