Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15352612 | 0.88 | ESR2 (0.34) | — | |
| SCHEMBL28214067 | 0.84 | ALDH1A1 (0.35) | KCNH2HRH3 | |
| SCHEMBL3487617 | 0.83 | SMN1; SMN2 (0.37) | KCNH2HRH3 | |
| SCHEMBL8194487 | 0.73 | DRD2 (0.51) | KCNH2HRH3 | |
| SCHEMBL28104157 | 0.71 | ALDH1A1 (0.38) | HTR1D | |
| SCHEMBL2890533 | 0.69 | ESR2 (0.32) | — | |
| SCHEMBL16958458 | 0.69 | TSHR (0.33) | — | |
| SCHEMBL21268135 | 0.69 | USP30 (0.31) | — | |
| SCHEMBL12856197 | 0.67 | QDPR (0.44) | IL2MAP4K1HTR1D | |
| SCHEMBL6265199 | 0.67 | CSF1R (0.46) | IL2MAP4K1KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052930-A2 | PREPARATION OF 4-ALK0XY-7- (TETRAHYDROPYRAN-4-YL) BENZOTHIAZOL-2-AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | disclosed |
| EP-1456202-A1 | BENZOTHIAZOLES | F. Hoffman-la Roche AG (CH) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053961-A1 | BENZOTHIAZOLES | F. HOFFMAN-LA ROCHE AG (CH) | 2003-07-03 | — | — | WO | disclosed |