Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 13/20 | 0.49 |
| ▸ | DRD2 | P14416 | 11/20 | 0.49 |
| ▸ | HTR1A | P08908 | 10/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401365 | 0.82 | DRD2 (0.56) | DRD4DRD2HTR1AGRM2ROCK2 | |
| Hydrochloric Acid SCHEMBL4589565 | 0.81 | DRD2 (0.55) | DRD4DRD2HTR1AGRM2ROCK2 | |
| SCHEMBL4589307 | 0.79 | SIGMAR1 (0.50) | DRD4DRD2HRH3ROCK2SLC6A4 | |
| SCHEMBL1401478 | 0.78 | DRD2 (0.56) | DRD4DRD2HTR1AGRM2ROCK2 | |
| SCHEMBL6589456 | 0.78 | HTR1A (0.52) | DRD4DRD2HTR1AKCNH2HRH3 | |
| SCHEMBL21662139 | 0.74 | DRD4 (0.61) | DRD4DRD2HTR1AKCNH2GRM2 | |
| SCHEMBL26446387 | 0.74 | DRD2 (0.65) | DRD4DRD2HTR1AKCNH2SLC6A4 | |
| SCHEMBL6586330 | 0.74 | HTR1A (0.52) | DRD4DRD2HTR1AKCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL21642938 | 0.73 | DRD4 (0.60) | DRD4DRD2HTR1AKCNH2GRM2 | |
| SCHEMBL27460494 | 0.70 | SIGMAR1 (0.39) | DRD4DRD2KCNH2HRH3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326720-B2 | Phenyl- and pyridylpiperidines with TNF activity | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | claimed |