Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.52 |
| ▸ | DRD4 | P21917 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589456 | 0.96 | HTR1A (0.52) | HTR1ADRD2DRD4KCNH2SIGMAR1 | |
| SCHEMBL6589037 | 0.85 | SIGMAR1 (0.44) | HTR1ADRD2DRD4SIGMAR1PARP1 | |
| SCHEMBL3453155 | 0.84 | DRD4 (0.52) | HTR1ADRD2DRD4KCNH2SIGMAR1 | |
| Ssr-150106 SCHEMBL1385047 | 0.83 | SIGMAR1 (0.48) | DRD2DRD4SIGMAR1PARP1 | |
| Ssr-150106 SCHEMBL29393331 | 0.83 | SIGMAR1 (0.48) | DRD2DRD4SIGMAR1PARP1 | |
| SCHEMBL6602138 | 0.83 | DRD4 (0.52) | HTR1ADRD2DRD4KCNH2SIGMAR1 | |
| SCHEMBL5149479 | 0.83 | HTR1A (0.53) | HTR1ADRD2DRD4KCNH2SIGMAR1 | |
| SCHEMBL6587088 | 0.82 | SIGMAR1 (0.52) | DRD2DRD4SIGMAR1PARP1 | |
| SCHEMBL6589317 | 0.82 | SIGMAR1 (0.45) | HTR1ADRD2DRD4SIGMAR1PARP1 | |
| SCHEMBL27476786 | 0.81 | SIGMAR1 (0.39) | DRD2DRD4KCNH2SIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B8 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI AVENTIS (FR) | 2004-12-15 | — | — | EP | disclosed |
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |
| EP-1226137-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001029026-A1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI-SYNTHELABO (FR) | 2001-04-26 | — | — | WO | disclosed |