Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | HCN1 | O60741 | 1/20 | 0.33 |
| ▸ | HCN3 | Q9P1Z3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11081075 | 0.72 | MEN1 (0.74) | MEN1KMT2AHSD11B1SIGMAR1SMN1; SMN2 | |
| SCHEMBL11085490 | 0.71 | MEN1 (0.77) | MEN1KMT2AHSD11B1SIGMAR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6926723 | 0.69 | ALDH1A1 (0.39) | MEN1KMT2ASIGMAR1POLBSLC6A2 | |
| SCHEMBL18390858 | 0.69 | MEN1 (0.69) | MEN1KMT2AHSD11B1SIGMAR1SMN1; SMN2 | |
| SCHEMBL11088640 | 0.69 | HSD11B1 (0.73) | MEN1KMT2AHSD11B1SIGMAR1POLB | |
| SCHEMBL5538611 | 0.68 | AKR1C1 (0.38) | MEN1KMT2ASIGMAR1POLBSMN1; SMN2 | |
| SCHEMBL8231613 | 0.66 | HSD11B1 (0.59) | MEN1KMT2AHSD11B1SIGMAR1POLB | |
| Hydrochloric Acid SCHEMBL23539353 | 0.66 | CA2 (0.43) | MEN1KMT2AHSD11B1SLC6A2 | |
| SCHEMBL4566295 | 0.66 | ALDH1A1 (0.38) | MEN1KMT2APOLBALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL6161721 | 0.66 | HSD11B1 (0.77) | MEN1KMT2AHSD11B1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |