Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404965 | 0.86 | DRD2 (0.56) | DRD2DRD4SIGMAR1ACHE | |
| SCHEMBL8819347 | 0.81 | ACHE (0.54) | DRD2DRD4SIGMAR1ACHEBCHE | |
| SCHEMBL222191 | 0.79 | ACHE (0.64) | SIGMAR1ACHEBCHE | |
| SCHEMBL4287273 | 0.79 | DRD2 (0.50) | DRD2DRD4SIGMAR1GAA | |
| SCHEMBL7501904 | 0.79 | DRD2 (0.63) | DRD2DRD4SIGMAR1ACHEBCHE | |
| SCHEMBL4289978 | 0.77 | BCHE (0.69) | DRD2DRD4SIGMAR1ACHEBCHE | |
| Hydrochloric Acid SCHEMBL9381094 | 0.77 | BCHE (0.69) | DRD2DRD4SIGMAR1ACHEBCHE | |
| SCHEMBL5259687 | 0.76 | DRD2 (0.54) | DRD2DRD4SIGMAR1GAA | |
| SCHEMBL8818483 | 0.76 | SIGMAR1 (0.64) | DRD2DRD4SIGMAR1ACHE | |
| SCHEMBL5039460 | 0.75 | HRH3 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910384-A1 | IMIDAZO [2,1-B]THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019344-A1 | IMIDAZO [2,1-B] THIAYOLE DERIVATIVES AS SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| WO-2006094246-A2 | N-ARYLMETHYL BENZAMIDE SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |