Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA7 | P43166 | 4/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30267852 | 1.00 | HSP90AB1 (0.61) | HSP90AB1ESR1ESR2CA12CA1 | |
| SCHEMBL7139595 | 0.85 | HSD17B3 (0.52) | HSP90AB1CA12CA1CA2CA7 | |
| SCHEMBL6357102 | 0.85 | HSP90AB1 (0.67) | HSP90AB1ESR1ESR2CA12CA1 | |
| SCHEMBL9041388 | 0.82 | MAPT (0.57) | HSP90AB1ESR2MEN1KMT2ACYP3A4 | |
| SCHEMBL7082841 | 0.81 | HTT (0.67) | MEN1KMT2AALDH1A1HTTKDM4E | |
| SCHEMBL28381250 | 0.81 | ATM (0.46) | HSP90AB1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL9040295 | 0.81 | MAPT (0.51) | HSP90AB1MEN1KMT2ACYP3A4ALDH1A1 | |
| SCHEMBL4624113 | 0.81 | ALDH1A1 (0.43) | HSP90AB1ESR1ESR2CA12CA1 | |
| SCHEMBL7078451 | 0.80 | FFAR1 (0.43) | HSP90AB1CA12CA1CA2CA7 | |
| SCHEMBL6092512 | 0.80 | NOS2 (0.61) | MEN1KMT2ACYP3A4ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3911660-B1 | PROCESS FOR PREPARATION OF 2-AMINO-5-HYDROXY PROPIOPHENONE | LAURUS LABS LTD (IN) | 2023-05-10 | — | — | EP | claimed |
| CN-115387113-A | Far infrared deodorization fabric and preparation method thereof | 郑喜才 | 2022-11-25 | — | — | CN | claimed |
| CN-113817133-A | Room-temperature self-crosslinking water-based nonionic polyurethane dispersion and preparation method and application thereof | 湖南松井新材料股份有限公司 | 2021-12-21 | — | — | CN | claimed |
| EP-1378505-B1 | METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS | YAKULT HONSHA KK (JP) | 2014-11-05 | — | — | EP | claimed |
| EP-1910269-B1 | METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES | AVRA LAB PVT LTD (IN) | 2013-09-18 | — | — | EP | claimed |
| US-8466287-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2013-06-18 | — | — | US | claimed |
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2012-02-16 | — | — | US | claimed |
| US-7910737-B2 | preparation method of 7-ethyl-10-hydroxycamptothecin from 4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione and 1-(2-amino-5 -hydroxyphenyl)-propan-1-one using higher reaction temperature and faster heating to that temperature in the presence of catalyst | FERMION OY (FI) | 2011-03-22 | — | — | US | claimed |
| US-7608740-B2 | Method of synthesizing key intermediates for the production of camptothecin derivatives | Avra Laboratories Pvt. Ltd (IN) | 2009-10-27 | — | — | US | claimed |
| EP-1846412-B1 | PROCESS FOR THE MANUFACTURING OF 7-ETHYL-10-HYDROXY CAMPTOTHECIN | FERMION OY (FI) | 2009-10-21 | — | — | EP | claimed |
| US-20080221358-A1 | Method of Synthesizing Key Intermediates for the Production of Camptothecin Derivatives | AVRA LABORATORIES PVT. LTD. (IN) | 2008-09-11 | — | — | US | claimed |
| US-7378555-B2 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2008-05-27 | — | — | US | claimed |
| US-20080103309-A1 | Process for the Manufacturing of 7-Ethyl-10-Hydroxy Camptothecin | FERMION OY (FI) | 2008-05-01 | — | — | US | claimed |
| EP-1910269-A2 | METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES | Avra Laboratories PVT. Ltd. (IN) | 2008-04-16 | — | — | EP | claimed |
| EP-1900740-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | Kabushiki Kaisha Yakult Honsha (JP) | 2008-03-19 | — | — | EP | claimed |
| WO-2007015259-A2 | METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES | AVRA LABORATORIES PVT. LTD. (IN) | 2007-02-08 | — | — | WO | claimed |
| US-20070010674-A1 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2007-01-11 | — | — | US | claimed |
| US-7126000-B2 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2006-10-24 | — | — | US | claimed |
| US-20040106830-A1 | Method of synthesizing camptothecin-relating compounds | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2004-06-03 | — | — | US | claimed |
| EP-1378505-A1 | METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS | Kabushiki Kaisha Yakult Honsha (JP) | 2004-01-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221358-A1 | Method of Synthesizing Key Intermediates for the Production of Camptothecin Derivatives | DHPS, TOP2A, HCCS | HSP90AB1 1603/4885ESR1 4250/4885ESR2 3610/4885 |
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | TKT, DCK, COASY | HSP90AB1 2430/4885ESR1 4510/4885ESR2 4455/4885 |
| US-20080103309-A1 | Process for the Manufacturing of 7-Ethyl-10-Hydroxy Camptothecin | TOP1, TOP2A, DHPS | HSP90AB1 534/4885ESR1 4097/4885ESR2 4339/4885 |
| US-20070010674-A1 | Method of synthesizing camptothecin-relating compounds | PAICS, DHPS, TOP2A | HSP90AB1 1368/4885ESR1 4616/4885ESR2 4419/4885 |
| US-20040106830-A1 | Method of synthesizing camptothecin-relating compounds | PAICS, DHPS, TOP2A | HSP90AB1 1669/4885ESR1 4685/4885ESR2 4465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.