Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032506 | 0.81 | CYP2E1 (0.40) | THRBKMT2APOLB | |
| SCHEMBL10425374 | 0.78 | KDM5A (0.42) | THRBKMT2ALMNA | |
| SCHEMBL304175 | 0.69 | LMNA (0.46) | KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL27398725 | 0.68 | LMNA (0.45) | KMT2ALMNA | |
| SCHEMBL9032448 | 0.61 | CYP2E1 (0.40) | THRBLMNA | |
| SCHEMBL2702033 | 0.61 | TDP1 (0.45) | THRBLMNA | |
| Hydrochloric Acid SCHEMBL27570535 | 0.60 | TDP1 (0.44) | THRBLMNA | |
| SCHEMBL11561900 | 0.59 | TSHR (0.39) | POLBLMNA | |
| SCHEMBL11561904 | 0.59 | KDM4E (0.39) | LMNA | |
| Water SCHEMBL27695531 | 0.57 | PKM (0.47) | KMT2APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008065500-A2 | HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| EP-1836207-A2 | TRIAZOLOPHTHALAZINES AS PDE2-INHIBITORS | Nycomed GmbH (DE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006072615-A2 | TRIAZOLOPHTHALAZINES AS PDE2-INHIBITORS | NYCOMED GMBH (DE) | 2006-07-13 | — | — | WO | disclosed |