Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10425374 | 0.85 | KDM5A (0.42) | CPB2THRBCPB1KMT2A | |
| SCHEMBL31487985 | 0.81 | CYP2E1 (0.40) | CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL9032448 | 0.81 | CYP2E1 (0.40) | CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL4590745 | 0.81 | THRB (0.35) | THRBPOLBKMT2A | |
| SCHEMBL304175 | 0.74 | LMNA (0.46) | KMT2A | |
| Hydrochloric Acid SCHEMBL27398725 | 0.72 | LMNA (0.45) | KMT2A | |
| SCHEMBL31416103 | 0.69 | KMT2A (0.40) | CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL9032483 | 0.67 | KDM5A (0.39) | CPB2CPB1KMT2A | |
| SCHEMBL151394 | 0.67 | SMYD3 (0.50) | CYP2E1CYP3A4CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL2702033 | 0.65 | TDP1 (0.45) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442348-B1 | Imidazole compounds, process for preparation, medicaments based on these compounds and some intermediates | HOECHST AG (DE) | 1996-07-17 | — | — | EP | disclosed |
| US-5356922-A | Treatment of disturbances in microcirculation | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| US-5232922-A | Cardiovascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0442348-A2 | Imidazole compounds, process for preparation, medicaments based on these compounds and some intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-21 | — | — | EP | disclosed |
| CN-1053919-A | New imidazolium compounds, its preparation method and based on medicament and some intermediate product of these compounds | HOECHST AG (DE) | 1991-08-21 | — | — | CN | disclosed |