Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590803 | 0.80 | PDE10A (0.46) | BCHEACHEPDE10ATRPC3HTR3A | |
| SCHEMBL4514691 | 0.80 | AURKA (0.41) | AURKACDK1CCNB1PDE9AKCNH2 | |
| SCHEMBL4510022 | 0.77 | PDE9A (0.53) | PDE9APDE1C | |
| SCHEMBL4590637 | 0.72 | SMN1; SMN2 (0.47) | TP53MAPTRAB9ALMNAKCNH2 | |
| SCHEMBL4591121 | 0.72 | AURKA (0.35) | AURKACDK1CCNB1PDE9AKCNH2 | |
| SCHEMBL4589851 | 0.66 | LMNA (0.45) | MAPTAURKACDK1CCNB1PDE9A | |
| SCHEMBL1353660 | 0.65 | CDK4 (0.63) | AURKACDK1CCNB1 | |
| SCHEMBL717865 | 0.65 | BCHE (1.00) | BCHEACHETRPC3HTR3ATP53 | |
| SCHEMBL2241920 | 0.65 | BCHE (1.00) | BCHEACHETRPC3HTR3ATP53 | |
| SCHEMBL27156475 | 0.64 | AURKA (0.46) | AURKACDK1CCNB1PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008055959-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-05-15 | — | — | WO | claimed |