Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29119510 | 0.94 | BAZ2B (0.54) | NPC1RAB9ABAZ2BALDH1A1KDM4E | |
| SCHEMBL2248318 | 0.94 | ACLY (0.53) | NPC1RAB9AMAOACYP1A2ADRA2A | |
| SCHEMBL4072601 | 0.85 | HTR1A (0.52) | NPC1RAB9AHTR1AALDH1A1KDM4E | |
| SCHEMBL29119496 | 0.84 | MLNR (0.51) | NPC1RAB9AMAOACYP1A2ADRA2A | |
| SCHEMBL1673429 | 0.84 | BAZ2B (0.69) | NPC1RAB9ABAZ2BALDH1A1POLB | |
| SCHEMBL2245582 | 0.84 | BAZ2B (0.64) | NPC1RAB9AMAOACYP1A2ADRA2A | |
| Hydrochloric Acid SCHEMBL8128910 | 0.84 | NPC1 (0.53) | NPC1RAB9ACYP1A2HTR1AHTR2A | |
| SCHEMBL29119487 | 0.83 | HRH3 (0.59) | NPC1RAB9AMAOACYP1A2ADRA2A | |
| SCHEMBL2244056 | 0.83 | BAZ2B (0.67) | NPC1RAB9AMAOACYP1A2ADRA2A | |
| SCHEMBL3652815 | 0.83 | NPC1 (0.49) | NPC1RAB9AMAOAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |
| EP-1910345-A1 | SUBSTITUTED AMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | Boehringer Ingelheim International GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| US-20070032473-A1 | Substituted amides and their use as medicaments | GERLACH KAI | 2007-02-08 | — | — | US | disclosed |
| WO-2007009963-A1 | SUBSTITUTED AMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032473-A1 | Substituted amides and their use as medicaments | OAT, HLA-B, BCAT2 | NPC1 2269/4885RAB9A 4519/4885MAOA 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.