Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590957 | 0.83 | HSP90AB1 (0.45) | HSP90AB1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL4591503 | 0.81 | HSP90AB1 (0.42) | HSP90AB1MCL1CYP11B1CYP11B2 | |
| SCHEMBL2323777 | 0.79 | PTGES (0.38) | HSP90AB1MCL1KDM5A | |
| SCHEMBL4590941 | 0.79 | MCL1 (0.39) | HSP90AB1MCL1KDM5A | |
| SCHEMBL4591479 | 0.79 | HSP90AB1 (0.34) | HSP90AB1CYP11B1CYP11B2TRPA1KDM5A | |
| SCHEMBL3633331 | 0.79 | KDM4E (0.41) | HSP90AB1MCL1 | |
| SCHEMBL4591744 | 0.78 | XDH (0.40) | HSP90AB1TRPA1 | |
| SCHEMBL4592503 | 0.77 | PDE4B (0.42) | HSP90AB1 | |
| SCHEMBL4591549 | 0.75 | DHODH (0.41) | HSP90AB1TRPA1KDM5A | |
| SCHEMBL4592321 | 0.75 | TRPA1 (0.42) | TRPA1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937688-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042421-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |