Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591503 | 0.85 | HSP90AB1 (0.42) | HSP90AB1LRRK2CYP11B1CYP11B2 | |
| SCHEMBL4590957 | 0.84 | HSP90AB1 (0.45) | HSP90AB1CYP11B1CYP11B2 | |
| SCHEMBL4590941 | 0.82 | MCL1 (0.39) | HSP90AB1KDM5ALRRK2 | |
| SCHEMBL3633331 | 0.82 | KDM4E (0.41) | HSP90AB1LRRK2 | |
| SCHEMBL2323777 | 0.82 | PTGES (0.38) | HSP90AB1KDM5ALRRK2 | |
| SCHEMBL4592503 | 0.80 | PDE4B (0.42) | HSP90AB1LRRK2 | |
| SCHEMBL4591279 | 0.79 | HSP90AB1 (0.35) | HSP90AB1KDM5ACYP11B1CYP11B2TRPA1 | |
| SCHEMBL4591744 | 0.79 | XDH (0.40) | HSP90AB1TRPA1 | |
| SCHEMBL4592321 | 0.78 | TRPA1 (0.42) | LRRK2TRPA1 | |
| SCHEMBL3409673 | 0.77 | VCAM1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937688-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| EP-1828194-A1 | TETRACYCLIC IMIDAZO-BENZODIAZEPINES AS GABA RECEPTORS MODULATORS | F. Hoffmann-Roche AG (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007042421-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |
| WO-2006063708-A1 | TETRACYCLIC IMIDAZO-BENZODIAZEPINES AS GABA RECEPTORS MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-22 | — | — | WO | disclosed |