Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7894752 | 0.83 | KDM4E (0.47) | KDM4ELMNAPOLBALDH1A1MAPT | |
| SCHEMBL2828050 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL2825300 | 0.79 | KDM4E (0.47) | KDM4ELMNAPOLBALDH1A1L3MBTL1 | |
| SCHEMBL11503765 | 0.78 | LMNA (0.50) | KDM4ELMNAGRIN2DGRIN3BGRIA1 | |
| SCHEMBL11837808 | 0.75 | POLB (0.64) | KDM4ELMNAPOLBALDH1A1MAPT | |
| SCHEMBL10787108 | 0.74 | LMNA (0.52) | KDM4ELMNAPOLBALDH1A1MAPT | |
| SCHEMBL4591971 | 0.73 | KDM4E (0.49) | KDM4ELMNAPOLBALDH1A1MAPT | |
| SCHEMBL4891897 | 0.73 | ALDH1A1 (0.42) | KDM4ELMNAPOLBALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL31151859 | 0.73 | POLB (0.37) | KDM4ELMNAPOLBALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL30898623 | 0.72 | POLB (0.41) | KDM4ELMNAPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101287738-B | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | disclosed |
| CN-101287738-A | Imidazo benzodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 2008-10-15 | — | — | CN | disclosed |
| EP-1937688-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042421-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |
| US-4159202-A | PHOTOCOPYING | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-26 | — | — | US | disclosed |