Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | ADGRF1 | Q5T601 | 1/20 | 0.39 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592414 | 0.84 | TRPM8 (0.34) | HTTALDH1A1 | |
| SCHEMBL4592935 | 0.83 | BCL2A1 (0.40) | MEN1KMT2ATP53MAPTSMN1; SMN2 | |
| SCHEMBL4592145 | 0.82 | BCL2A1 (0.41) | C5AR1GPR183ADGRF1GPR65DRD2 | |
| SCHEMBL4592271 | 0.80 | RAB9A (0.40) | C5AR1GPR183ADGRF1GPR65HTT | |
| SCHEMBL4592274 | 0.80 | RAB9A (0.40) | C5AR1GPR183ADGRF1GPR65HTT | |
| SCHEMBL4592302 | 0.80 | RAB9A (0.40) | C5AR1GPR183ADGRF1GPR65HTT | |
| SCHEMBL4592189 | 0.77 | C5AR1 (0.37) | C5AR1GPR183ADGRF1GPR65DRD2 | |
| SCHEMBL4591647 | 0.76 | GCGR (0.34) | CYP3A4 | |
| SCHEMBL4593125 | 0.76 | BCL2A1 (0.43) | TP53MAPTSMN1; SMN2BCL2A1RNF4 | |
| SCHEMBL4592269 | 0.76 | PDK1 (0.38) | TP53UBE2MDCUN1D1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885691-A1 | C5A RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2008-02-13 | — | — | EP | claimed |
| WO-2006128670-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-12-07 | — | — | WO | claimed |