Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012742 | 0.82 | MEN1 (0.40) | SLC6A4MEN1KMT2AOPRD1 | |
| SCHEMBL4591521 | 0.80 | SLC6A3 (0.45) | SLC6A4 | |
| SCHEMBL23924861 | 0.76 | SLC6A3 (0.40) | SLC6A4 | |
| SCHEMBL3655052 | 0.75 | SLC6A4 (0.41) | SLC6A4 | |
| SCHEMBL30899722 | 0.75 | OPRK1 (0.42) | SLC6A4HRH3 | |
| SCHEMBL8481404 | 0.75 | OPRK1 (0.42) | SLC6A4HRH3 | |
| SCHEMBL4591913 | 0.72 | MEN1 (0.46) | MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL1177871 | 0.71 | TRPV1 (0.37) | MEN1KMT2AMAPK1CYP2C9 | |
| SCHEMBL7349981 | 0.70 | LMNA (0.32) | MEN1KMT2ACYP2C9 | |
| SCHEMBL9493823 | 0.69 | AKR1B1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945212-A1 | TREATMENT OF DIABETES | NEUROSEARCH A/S (DK) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007051594-A1 | TREATMENT OF DIABETES | NEUROSEARCH A/S (DK) | 2007-05-10 | — | — | WO | disclosed |