Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | PPARD | Q03181 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | BCL2 | P10415 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071873 | 0.81 | PLA2G4A (0.51) | PLA2G4APPARGPPARDPPARAMCL1 | |
| SCHEMBL5068779 | 0.81 | PLA2G4A (0.44) | PLA2G4APPARGPPARDPPARAMCL1 | |
| SCHEMBL30888879 | 0.78 | PLAU (0.57) | PPARGHDAC8HDAC6HDAC11HDAC3 | |
| SCHEMBL15971036 | 0.78 | PLAU (0.57) | PPARGHDAC8HDAC6HDAC11HDAC3 | |
| SCHEMBL5068315 | 0.77 | TUBB4A (0.57) | PLA2G4APPARGPPARDPPARAHDAC8 | |
| SCHEMBL28607801 | 0.76 | KMT2A (0.60) | PLA2G4APPARGPPARDPPARA | |
| SCHEMBL2983210 | 0.76 | PLA2G4A (0.48) | PLA2G4APPARGPPARDPPARAHDAC8 | |
| SCHEMBL5387474 | 0.76 | TUBB4A (0.59) | PLA2G4APPARGHDAC8HDAC6HDAC11 | |
| SCHEMBL28586559 | 0.76 | RORC (0.50) | PLA2G4APPARGPPARDPPARAMCL1 | |
| SCHEMBL1609166 | 0.76 | MCL1 (0.63) | PLA2G4APPARGPPARDPPARAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807398-B1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-06-25 | — | — | EP | disclosed |