Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 2/20 | 0.59 |
| ▸ | TUBB | P07437 | 2/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.59 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.59 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.59 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.59 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.59 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.53 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934703 | 0.87 | PLA2G4A (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5387046 | 0.87 | MCL1 (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16492908 | 0.87 | TUBB4A (0.59) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL30622502 | 0.87 | MCL1 (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL18295992 | 0.85 | TUBB4A (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5068315 | 0.85 | TUBB4A (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1749895 | 0.84 | PLA2G4A (0.59) | PLA2G4AHCAR3PLGPLAU | |
| SCHEMBL15921713 | 0.84 | PLA2G4A (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2983210 | 0.83 | PLA2G4A (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28607801 | 0.83 | KMT2A (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11638760-B2 | Pyrrolobenzodiazepine antibody conjugates | MERSANA THERAPEUTICS, INC. (US) | 2023-05-02 | — | — | US | disclosed |
| CN-112759541-B | Indole-like derivatives and uses thereof | 复旦大学 | 2023-03-17 | — | — | CN | disclosed |
| CN-112759541-A | Indole-like derivatives and uses thereof | 复旦大学 | 2021-05-07 | — | — | CN | disclosed |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | PHARMACYCLICS LLC | 2018-10-25 | — | — | US | disclosed |
| EP-3310776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | Pharmacyclics LLC (US) | 2018-04-25 | — | — | EP | disclosed |
| CN-107709315-A | The inhibitor of bruton's tyrosine kinase | 药品循环有限责任公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-104812749-B | Indolecarboxamide derivant as P2X7 receptor antagonist | 埃科特莱茵药品有限公司 | 2016-12-14 | — | — | CN | disclosed |
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |
| CN-104812749-A | Iindole carboxamide derivatives as p2x7 receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2015-07-29 | — | — | CN | disclosed |
| WO-2012170554-A1 | N-BIPHENYLMETHYLINDOLE MODULATORS OF PPARG | KAMENECKA THEODORE MARK (US) | 2012-12-13 | — | — | WO | disclosed |
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| CN-1835944-A | Quinolyl amide derivatives as CCR-5 antagonists | SCHERING AG (DE) | 2006-09-20 | — | — | CN | disclosed |
| EP-1633737-A1 | QUINOLYL AMIDE DERIVATIVES AS CCR-5 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-03-15 | — | — | EP | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
| US-20050020605-A1 | Quinolyl amide derivatives as CCR-5 antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-01-27 | — | — | US | disclosed |
| WO-2004113323-A1 | QUINOLYL AMIDE DERIVATIVES AS CCR-5 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020605-A1 | Quinolyl amide derivatives as CCR-5 antagonists | CCRL2, CCR5, CCR1 | TUBB4A 1883/4885TUBB 1916/4885TUBA3C 1635/4885 |
| US-20210070748-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | TUBB4A 2043/4885TUBB 1303/4885TUBA3C 2095/4885 |
| US-11638760-B2 | Pyrrolobenzodiazepine antibody conjugates | GABRA4, GABRA1, GABRA2 | TUBB4A 530/4885TUBB 427/4885TUBA3C 431/4885 |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | TUBB4A 1266/4885TUBB 1148/4885TUBA3C 1231/4885 |
| US-20180305348-A1 | INHIBITORS OF BRUTONS TYROSINE KINASE | BTK, LYN, LCK | TUBB4A 2043/4885TUBB 1303/4885TUBA3C 2095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.